Priestly B G, Plaa G L
Arch Int Pharmacodyn Ther. 1976 Sep;223(1):132-41.
Male mice treated with nicotine hydrochloride either acutely (5 mg/kg i.p.) or subchronically (5 mg/kg i.p. daily for 3 weeks; 25 mg/liter in drinking water for 2-3 months) showed no evidence of hepatic dysfunction, as measured by serum glutamic-pyruvic transaminase or serum alkaline phosphatase activities. Neither acute nor subchronic administration modified the hepatotoxic response to a potent hepatotoxin (carbon tetrachloride), nor that of less potent hepatotoxins chloroform or 1, 1, 1-trichloroethane, nor was the cholestatic effect of alpha-naphthylisothiocyanate modified.
用盐酸尼古丁急性处理（腹腔注射5毫克/千克）或亚慢性处理（每天腹腔注射5毫克/千克，持续3周；饮用水中含25毫克/升，持续2 - 3个月）的雄性小鼠，通过血清谷丙转氨酶或血清碱性磷酸酶活性测量，未显示肝功能障碍的迹象。急性或亚慢性给药均未改变对强效肝毒素（四氯化碳）的肝毒性反应，对效力较弱的肝毒素氯仿或1,1,1 - 三氯乙烷的反应也未改变，α - 萘基异硫氰酸酯的胆汁淤积作用也未改变。
