Gradiski D, Bonnet P, Duprat P, Zissu D, Magadur J L, Guenier J P
Toxicol Eur Res. 1981 Jul;3(4):201-6.
Industrial chemicals are seldom used as pure substances; hazards resulting from exposure to mixtures have, however not been solved. Our study deals with chronic inhalation toxicity of a mixture of benzene and toluene; few studies have been completed on this subject. Our results show: - leucopenia with benzene alone, at a concentration of 50 p.p.m., that is not detectable in the presence of toluene; - metabolic variations consisting in: a decrease in the phenol urinary rate versus time with benzene alone; a sharp decrease of this rate from the third month of exposure on, in presence of toluene.
工业化学品很少以纯物质形式使用；然而，接触混合物所产生的危害尚未得到解决。我们的研究涉及苯和甲苯混合物的慢性吸入毒性；关于这个主题的研究很少。我们的结果表明：——单独使用浓度为50 ppm的苯会导致白细胞减少，而在甲苯存在的情况下无法检测到；——代谢变化包括：单独使用苯时，尿酚排泄率随时间下降；在甲苯存在的情况下，从接触的第三个月起，该排泄率急剧下降。
