Heywood R
Toxicol Lett. 1981 Aug;8(6):349-58. doi: 10.1016/0378-4274(81)90125-9.
In a survey of the toxicological profiles of 50 compounds in rodent and non-rodent species, sensitive criteria of toxicity were found to be the simple characteristics, such as clinical observation of the living animal, growth and organ weight analysis, liver and kidney function tests and histological examination of selected tissues. There was poor correlation of target organ toxicity across the species. For this reason safety evaluation should not be based on the demonstration of target organ toxicity, but on the absence of toxic signs. A step by step approach, based on the biological activity of the compound, would provide more meaningful data for safety evaluation than the standard toxicological studies in a rodent and non-rodent species.
在一项对50种化合物在啮齿动物和非啮齿动物物种中的毒理学概况的调查中，发现毒性的敏感标准是一些简单的特征，如对活体动物的临床观察、生长和器官重量分析、肝肾功能测试以及对选定组织的组织学检查。不同物种间靶器官毒性的相关性较差。因此，安全性评估不应基于靶器官毒性的证明，而应基于无毒性迹象。基于化合物生物活性的逐步方法，将比在啮齿动物和非啮齿动物物种中进行的标准毒理学研究提供更有意义的安全性评估数据。
