Cozens D D, Hughes E W, Clark R, Offer J M
Toxicol Lett. 1981 Sep;9(1):77-80. doi: 10.1016/0378-4274(81)90178-8.
Lentinan, a polysaccharide [(1 leads to 3)-beta-D-glucan], at 0.1, 1.0 and 5.0 mg/kg/day was administered i.v. to rats once daily from day 15 of pregnancy to day 21 post partum. All animals were allowed to deliver their young and selected animals of the F1 generation were retained without further treatment, to provide F2 offspring. Reactions to treatment were generally dose-related and included bruising of the tail and swelling and discolouration of the pinnae. Animals at 5.0 mg/kg/day sometimes showed swollen hind limbs and cutaneous lesions of the tail. Mean spleen weight in females was increased at all dosages, more so at 1.0 and 5.0 mg/kg/day. There was no evidence of an adverse effect on litter characteristics, including the pre-weaning development of the F1 offspring, or that treatment of the F0 parents adversely affected post-weaning development and reproductive performance of the F1 offspring.
香菇多糖，一种多糖[（1→3）-β-D-葡聚糖]，以0.1、1.0和5.0毫克/千克/天的剂量从妊娠第15天至产后第21天每天静脉注射给大鼠一次。所有动物均让其分娩幼崽，并选择F1代的部分动物不再进一步处理，以提供F2代后代。对治疗的反应一般与剂量相关，包括尾巴瘀伤以及耳廓肿胀和变色。5.0毫克/千克/天剂量组的动物有时会出现后肢肿胀和尾巴皮肤损伤。所有剂量组雌性动物的脾脏平均重量均增加，在1.0和5.0毫克/千克/天剂量组增加得更多。没有证据表明对窝仔特征有不良影响，包括F1代后代断奶前的发育，也没有证据表明对F0代亲本的处理会对F1代后代断奶后的发育和生殖性能产生不利影响。
