香菇多糖对比格犬的静脉注射毒性。

The intravenous toxicity of lentinan to the beagle dog.

作者信息

Chesterman H, Heywood R, Allen T R, Street A E, Edmondson N A, Prentice D E

出版信息

Toxicol Lett. 1981 Sep;9(1):87-90. doi: 10.1016/0378-4274(81)90180-6.

Abstract

The i.v administration of lentinan to the Beagle dog induced changes in the cytoplasm of macrophagic cells in the liver, spleen, kidney, lungs, lymph nodes, small intestine. Electron-lucent or filamentous inclusions were demonstrated in the liver, kidney and spleen. A dose level of 0.5 mg/kg/day was without adverse effect.

摘要

给比格犬静脉注射香菇多糖会引起肝脏、脾脏、肾脏、肺、淋巴结和小肠中巨噬细胞细胞质的变化。在肝脏、肾脏和脾脏中发现了电子透明或丝状包涵体。剂量水平为0.5毫克/千克/天无不良反应。