在小鼠神经母细胞瘤细胞培养物中测试有机溶剂、重金属和滴滴涕的急性毒性。

Acute toxicity of organic solvents, heavy metals and DDT tested in cultures of mouse neuroblastoma cells.

作者信息

Peterson A, Lewné M, Walum E

出版信息

Toxicol Lett. 1981 Oct;9(2):101-6. doi: 10.1016/0378-4274(81)90024-2.

Abstract

To test the toxicity of some substances, known to affect the nervous system i.e. organic solvents, heavy metals and DDT, their ability to cause cell detachment of cultured mouse neuroblastoma cells was investigated. A TD25 value was obtained by graphic estimation of the concentration needed to cause 25% of the total cell number to detach. These TD25 values were compared with LD50 values obtained from the literature and a correlation was found.

摘要

为了测试某些已知会影响神经系统的物质（即有机溶剂、重金属和滴滴涕）的毒性，研究了它们导致培养的小鼠神经母细胞瘤细胞脱离的能力。通过图形估计导致25%的总细胞数脱离所需的浓度来获得TD25值。将这些TD25值与从文献中获得的LD50值进行比较，发现了相关性。