卡巴咪嗪-乙醇相互作用：脑电图反应与脑脊液乙醛之间缺乏关联。

The calcium carbimide-ethanol interaction: lack of relation between electroencephalographic response and cerebrospinal fluid acetaldehyde.

作者信息

Hillbom M E, Lindros K O, Larsen A

出版信息

Toxicol Lett. 1981 Oct;9(2):113-9. doi: 10.1016/0378-4274(81)90026-6.

Abstract

Penetration of acetaldehyde into cerebrospinal fluid (CSF) was studied in healthy human volunteers during calcium carbimide-ethanol interaction. CSF was sampled via lumbar puncture and blood from a cubital vein. CSF and blood acetaldehyde concentrations varied from 1 to 41 and from 22 to 138 mumol/l, respectively. The results indicate that acetaldehyde penetrates the human blood-liquor barrier. Computer analysis of electroencephalograms (EEGs) recorded during the interaction showed reduction in alpha activity with a concomitant increase in delta activity. The changes were similar to those previously observed during 'normal' ethanol intoxication.

摘要

在健康人类志愿者中，研究了在卡马西平-乙醇相互作用期间乙醛进入脑脊液（CSF）的情况。通过腰椎穿刺采集脑脊液，并从肘静脉采集血液。脑脊液和血液中的乙醛浓度分别在1至41μmol/L和22至138μmol/L之间变化。结果表明乙醛可穿透人体血-脑屏障。对相互作用期间记录的脑电图（EEG）进行计算机分析显示，α波活动减少，同时δ波活动增加。这些变化与先前在“正常”乙醇中毒期间观察到的变化相似。