Hoover D J, Brien J F
Can J Physiol Pharmacol. 1981 Jan;59(1):65-70. doi: 10.1139/y81-011.
Ethanol was administered to rats by oral intubation 3 h after intraperitoneal administration of calcium carbimide. Increased blood acetaldehyde concentration and the presence of acetaldehyde in brain were found for the calcium carbimide--ethanol interaction. There was no detectable brain acetaldehyde for ethanol administration following saline treatment. The magnitude of the acetaldehyde concentration in blood and brain during the calcium carbimide--ethanol interaction was directly dependent on the doses of calcium carbimide (0.7, 3.5, 7.0 mg/kg) and ethanol (0.5, 1.0, 1.5 g/kg). There was an exponential relationship between brain acetaldehyde concentration and blood acetaldehyde concentration. The threshold blood acetaldehyde concentration, above which acetaldehyde was found in brain, was approximately 6 micrograms/mL.
在腹腔注射双硫仑3小时后，通过经口插管给大鼠施用乙醇。发现双硫仑 - 乙醇相互作用会使血液中乙醛浓度升高且大脑中存在乙醛。盐水处理后给予乙醇时，大脑中未检测到乙醛。双硫仑 - 乙醇相互作用期间血液和大脑中乙醛浓度的大小直接取决于双硫仑（0.7、3.5、7.0毫克/千克）和乙醇（0.5、1.0、1.5克/千克）的剂量。大脑乙醛浓度与血液乙醛浓度之间存在指数关系。大脑中发现乙醛的血液乙醛浓度阈值约为6微克/毫升。
