Todd M M, Dunlop B J, Shapiro H M, Chadwick H C, Powell H C
Stroke. 1981 Nov-Dec;12(6):808-15. doi: 10.1161/01.str.12.6.808.
A minimally invasive and standardized means of resuscitating cats from defined periods of ventricular fibrillation (VF) has been developed using methods little different from human cardiopulmonary resuscitation techniques. After a 12 min arrest, the rate of successful resuscitation is greater than 90%, witha resuscitation time of 2.5 +/- 0.7 (SD) min, and a 7 day survival of 70%. All deaths could be related to a specific electroencephalographic event observed acutely post-resuscitation, and were not due to obvious non-neurologic complications. The post-arrest variation in a variety of parameters (blood pressure, blood gases, etc.) was minimal, and the degree of neurologic damage was severe enough to permit evaluation. Such a model is clinically relevant, and may be useful in studying the pathophysiology of global ischemia, and assessing different types of post-arrest therapy.
一种与人类心肺复苏技术差别不大的方法已被用于开发一种微创且标准化的手段，用于使猫从特定时长的心室颤动（VF）中复苏。在12分钟的心脏停搏后，成功复苏率大于90%，复苏时间为2.5 +/- 0.7（标准差）分钟，7天生存率为70%。所有死亡都与复苏后急性观察到的特定脑电图事件有关，而非明显的非神经系统并发症所致。心脏停搏后各种参数（血压、血气等）的变化极小，神经损伤程度严重到足以进行评估。这样一个模型具有临床相关性，可能有助于研究全脑缺血的病理生理学，并评估不同类型的心脏停搏后治疗。
