Endoscopic evaluation of gastric tolerance to fenclofenac.

Gastrointestinal irritation is a common consequence of treatment with many non-steroidal anti-inflammatory agents. An open tolerance study with endoscopic control employing fenclofenac in doses of 900 or 1200 mg daily in ten patients with osteoarthrosis, was carried out over an eight week period. The principal aim of the study was to evaluate the effect of fenclofenac on the gastroduodenal mucosa in a selected group of patients with osteoarthrosis and with a history of gastric intolerance to other non-steroidal anti-inflammatory agents. All patients tolerated fenclofenac well and showed clinical improvement.