用活菌株ts-S34经鼻内接种对豚鼠进行支气管败血波氏杆菌感染的预防。
Prophylaxis of Bordetella bronchiseptica infection in guinea pigs by intranasal vaccination with live strain ts-S34.
作者信息
Shimizu T
出版信息
Infect Immun. 1978 Nov;22(2):318-21. doi: 10.1128/iai.22.2.318-321.1978.
Abstract
The temperature-sensitive mutant strain, ts-S34, of Bordetella bronchiseptica, which cannot grow at or above the temperature 34 degrees C, has been studied in guinea pigs. The strain grew to moderate numbers in the nasal turbinates but did not grow in the lungs. Guinea pigs given strain ts-S34 developed moderate levels of serum antibody. This strain also induced very high resistance to subsequent intranasal challenge with 4,000X the 50% lethal dose of virulent strain S1 of B. bronchiseptica. In these studies, it appeared that the ts-S34 strain had favorable properties for potential use as a live attenuated vaccine.
摘要
支气管败血波氏杆菌的温度敏感突变株ts - S34在34摄氏度及以上温度不能生长，已在豚鼠身上进行了研究。该菌株在鼻甲中生长到中等数量，但在肺部不生长。接种ts - S34菌株的豚鼠产生了中等水平的血清抗体。该菌株还诱导了对随后用4000倍支气管败血波氏杆菌强毒株S1的50%致死剂量进行鼻内攻击的极高抵抗力。在这些研究中，ts - S34菌株似乎具有作为减毒活疫苗潜在使用的有利特性。
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