Watanabe T
Acta Pathol Jpn. 1981 Sep;31(5):717-32. doi: 10.1111/j.1440-1827.1981.tb02798.x.
The muco-muscularis ratio (MMR) of the pyloric antrum was examined in "normal' stomachs and stomachs with chronic gastritis, small chronic gastric ulcers, and duodenal ulcers. The majority of normal stomachs revealed a figure of less than 1 (average 0.803). In chronic gastritis, the MMR was rather high (average 1.127). This fact indicated that the characteristic feature in this condition was atrophy of the muscularis externa rather than that of the mucous membrane. The MMR in stomachs with small chronic ulcers showed no significant difference compared with that of normal samples. Although there were greater fluctuations in MMR of stomachs in cases with duodenal ulcers, it was generally high (average 1.233). The age distribution in this group simulated that of the chronic gastritis group. Microscopical examination of the gastric mucosa of the pyloric antrum in chronic gastritis revealed physiological inflammatory changes appearing 20 years earlier than those of aging process. The pattern of microscopical findings in the stomach with small chronic ulcers was similar to that of normal stomach, and the formation of ulcer was interpreted to be a result of an episode occurring locally. In the stomach of cases with duodenal ulcers, other than the low incidence of intestinal metaplasia, the general findings were similar to those seen in chronic gastritis.
对“正常”胃以及患有慢性胃炎、小型慢性胃溃疡和十二指肠溃疡的胃的幽门窦黏膜-肌层比例（MMR）进行了检查。大多数正常胃的该比例小于1（平均0.803）。在慢性胃炎中，MMR相当高（平均1.127）。这一事实表明，这种情况下的特征是外肌层萎缩而非黏膜萎缩。患有小型慢性溃疡的胃的MMR与正常样本相比无显著差异。虽然十二指肠溃疡病例中胃的MMR波动更大，但总体较高（平均1.233）。该组的年龄分布与慢性胃炎组相似。对慢性胃炎患者幽门窦胃黏膜的显微镜检查显示，生理性炎症变化比衰老过程中的变化早20年出现。小型慢性溃疡胃的显微镜检查结果模式与正常胃相似，溃疡的形成被解释为局部发生的一次发作的结果。在十二指肠溃疡病例的胃中，除肠化生发生率较低外，总体发现与慢性胃炎所见相似。
