Eller A, Nyakas C, Szabó G, Endröczi E
Acta Physiol Acad Sci Hung. 1981;57(3):205-11.
Male rats were trained to swim for 9-10 days to assess the effect of chronic stress on the capacity and affinity of specific glucocorticoid binding in the cytosol fraction of myocardial tissue. A significant decrease in the binding capacity for corticosterone (Cpd B) was found 24 hours after the last swimming test, while the affinity constant remained unchanged. Contrary to Cpd B binding, there was no change in the capacity of dexamethasone binding, and there was no decrease in the Cpd B binding capacity in rats which had been adrenalectomized 2 days prior to the training period. We conclude that daily swimming for 9-10 days alters the numbers of cytoplasmic Cpd B binding sites in the face of increased adrenocortical activity, while not affecting dexamethasone binding in the cytosol fraction of myocardial tissue.
对雄性大鼠进行9至10天的游泳训练，以评估慢性应激对心肌组织胞浆部分中特定糖皮质激素结合能力和亲和力的影响。在最后一次游泳测试24小时后，发现皮质酮（化合物B）的结合能力显著下降，而亲和常数保持不变。与化合物B的结合情况相反，地塞米松的结合能力没有变化，并且在训练期前两天进行了肾上腺切除的大鼠中，化合物B的结合能力也没有下降。我们得出结论，在肾上腺皮质活性增加的情况下，每天游泳9至10天会改变心肌组织胞浆中化合物B结合位点的数量，而不影响地塞米松在心肌组织胞浆部分的结合。
