正常人类妊娠头三个月羊水中的促红细胞生成素及红细胞生成抑制剂。
Erythropoietin and the inhibitor of erythropoiesis in the amniotic fluid during the first trimester of normal human pregnancy.
作者信息
Lazewska M
出版信息
Acta Physiol Pol. 1981 May-Jun;32(3):327-32.
The erythropoietic activity of the amniotic fluid from the 1st trimester of pregnancy and of blood plasma of pregnant women was tested biologically on polycythaemic mice by means of radiolabelled 59Fe. It was found that the amniotic fluid exhibits an erythropoietic activity. Then, using Sephadex G-100 gel filtration several fractions of the fluid were separated chromatographically; they were tested on polycythaemic mice for their erythropoiesis-stimulatory and inhibitory activity. It was found that fraction II proteins (mol. w. about 38 000) acted as an erythropoiesis stimulator, while fractions V and VI (mol. w. 6 900 and 4 000, respectively) showed inhibitory properties.
利用放射性标记的59Fe，对妊娠早期羊水和孕妇血浆的促红细胞生成活性在红细胞增多症小鼠上进行了生物学测试。发现羊水具有促红细胞生成活性。然后，使用葡聚糖G - 100凝胶过滤法对该液体进行色谱分离得到几个组分；在红细胞增多症小鼠上测试了它们的促红细胞生成刺激和抑制活性。发现组分II的蛋白质（分子量约为38000）起到促红细胞生成刺激剂的作用，而组分V和VI（分子量分别为6900和4000）表现出抑制特性。
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