Lundberg C, Smedegård G
Acta Physiol Scand. 1981 Apr;111(4):491-6. doi: 10.1111/j.1748-1716.1981.tb06768.x.
Regional skin blood flows in the trunk were measured by means of radioactive labeled microspheres in anesthetized rats and monkeys. Mean arterial pressure, heart rate, cardiac output and arterial pH, pO2 and pCO2 were registered and body and ambient air temperature were kept constant for the duration of the experiments. The blood flows were determined on a total of 6 skin samples, 2 samples each from the thoracic, lumbar and sacral regions. The reproducibility of the microsphere technique for measurements were given with a 10 min interval. The coefficient of variation varied with the region from 10.3 to 22.7%. In both species the skin blood flows in the thoracic regions were significantly higher than in the lumbar and sacral regions (P less than 0.05). The skin blood flows in the thoracic region of the rat ranged from 39-45 ml.min-1.100 g-1, in the lumbar region from 32-33 and in the sacral region from 29-30. In the monkeys the corresponding values for the different regions were: thoracic: 7-9, lumbar 5-7 and sacral: 4-7 ml.min-1.100 g-1, respectively. Our results support the use of radioactive microspheres for skin blood flow measurements, and demonstrate the existence of regional differences in the skin blood flow of the trunk. We suggest that this may be an important consideration during the development, and interpretation of data from experimental models in which skin blood flow is important.
在麻醉的大鼠和猴子身上，通过放射性标记微球测量躯干区域的皮肤血流量。记录平均动脉压、心率、心输出量以及动脉血pH值、pO2和pCO2，并在实验过程中保持体温和环境温度恒定。总共在6个皮肤样本上测定血流量，分别从胸部、腰部和骶部区域各取2个样本。微球技术测量的可重复性以10分钟的间隔给出。变异系数因区域而异，范围为10.3%至22.7%。在这两个物种中，胸部区域的皮肤血流量均显著高于腰部和骶部区域（P小于0.05）。大鼠胸部区域的皮肤血流量范围为39 - 45 ml·min-1·100 g-1，腰部区域为32 - 33，骶部区域为29 - 30。在猴子中，不同区域的相应值分别为：胸部：7 - 9，腰部5 - 7，骶部：4 - 7 ml·min-1·100 g-1。我们的结果支持使用放射性微球进行皮肤血流量测量，并证明了躯干皮肤血流量存在区域差异。我们认为，在开发以及解释皮肤血流量起重要作用的实验模型数据时，这可能是一个重要的考虑因素。
