Katevuo K, Kanto J, Kleimola T
Int J Clin Pharmacol Biopharm. 1978 Dec;16(12):585-8.
In subsequent studies 300 mg of proxyphylline (Group 1) and 1 amp Baralgin (Group 2) were administered intravenously to 20 patients in order to study the relaxing effect of proxyphylline and Baralgin on the contracted gallbladder in connection with routine oral cholecystography. After the standard contraction meal (200 ml cream) the intravenously administered proxyphylline had no relaxing effect on the human gallbladder, whereas Baralgin caused a significant dilation. The dilation effect lasted throughout the whole study period (60 min). Proxyphylline concentrations in the serum, determined by gas-liquid chromatography, proved to be on the therapeutic level which is said to be effective in the treatment of obstructive pulmonary disease. Because with proxyphylline no dilation effect on the gallbladder was found, the clinical spasmolytic response to proxyphylline during an acute attack of pain in a patient suffering from gallstones seems to be questionable. Baralgin caused a significant dilation effect on the gallbladder, and it seems to be a useful agent in an acute gallstone attack.
在后续研究中，为了研究丙羟茶碱和巴拉丁对常规口服胆囊造影时收缩胆囊的松弛作用，对20名患者静脉注射300毫克丙羟茶碱（第1组）和1安瓿巴拉丁（第2组）。在标准收缩餐（200毫升奶油）后，静脉注射的丙羟茶碱对人体胆囊没有松弛作用，而巴拉丁则引起了显著扩张。扩张效应在整个研究期间（60分钟）持续存在。通过气液色谱法测定的血清中丙羟茶碱浓度被证明处于治疗水平，据说该水平对阻塞性肺病的治疗有效。由于未发现丙羟茶碱对胆囊有扩张作用，因此对于患有胆结石的患者在急性疼痛发作期间对丙羟茶碱的临床解痉反应似乎值得怀疑。巴拉丁对胆囊有显著的扩张作用，它似乎是急性胆结石发作时的一种有用药物。
