Katevuo K, Kanto J, Manell D, Mäntylä R
Int J Clin Pharmacol Biopharm. 1978 May;16(5):220-2.
In a double-blind study, 40 mg of papaverine (Group I) or the same amount of placebo (1.0 ml of physiological saline, Group II)was injected intravenously in 19 patients to study the effect of papaverine on the contractility of the gallbladder in connection with routine oral cholecystography. In both groups a standard contraction meal (200 ml of cream) caused a significant contraction of the gallbladder (at 30 minutes). Thereafter, intravenously administered papaverine significantly inhibited further contraction caused by the fatty meal, but no significant dilatation was observed. This difference between the two groups lasted throughout the whole study period to 60 minutes after the drug administration. This time period mainly consisted of the distributional alpha-phase of the drug concentrations determined by gas chromatography in the serum. Because no dilation effect on the gallbladder was found, the clinical spasmolytic response to papaverine during an acute attack of pain in a patient with gallstones seems to be questionable.
在一项双盲研究中，对19名患者静脉注射40毫克罂粟碱（第一组）或等量的安慰剂（1.0毫升生理盐水，第二组），以研究罂粟碱对胆囊收缩性的影响，并与常规口服胆囊造影相关联。在两组中，标准收缩餐（200毫升奶油）均导致胆囊在30分钟时出现显著收缩。此后，静脉注射的罂粟碱显著抑制了由脂肪餐引起的进一步收缩，但未观察到明显扩张。两组之间的这种差异在整个研究期间持续至给药后60分钟。该时间段主要由血清中通过气相色谱法测定的药物浓度的分布α相组成。由于未发现对胆囊的扩张作用，罂粟碱在胆结石患者急性疼痛发作期间的临床解痉反应似乎值得怀疑。
