虹鳟（Salmo gairdneri）中与温度相关的磺胺二甲嘧啶吸收与排泄

Temperature related absorption and excretion of sulphadimidine in rainbow trout, Salmo gairdneri.

作者信息

Borgan A, Odegaard S, Bergsjø T

出版信息

Acta Vet Scand. 1981;22(2):211-7. doi: 10.1186/BF03547510.

DOI:10.1186/BF03547510

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8300508/

Abstract

The main purpose of the present study was to see if a kinetic model and a computer program for characterizing the rate of uptake and clearance of chemicals in aquatic organisms (Biofac, OECD’s Chemicals Testing Programme) was applicable to pharmacokinetic studies in fish. The program seems suitable for such studies. The effect of temperature upon rate of absorption of sulphadimidine from medicated water and elimination of the same drug was investigated in rainbow trout. A rise in the temperature from 7° C to 14° C more than doubled the calculated rate constants of absorption and elimination. The biological half life (t ) and the time to reach 90 % of steady state (t) at 14° C were approximately half the values at 7° C.

摘要

本研究的主要目的是探讨一种用于表征水生生物体内化学物质摄取和清除速率的动力学模型及计算机程序（Biofac，经合组织化学品测试计划）是否适用于鱼类的药代动力学研究。该程序似乎适用于此类研究。在虹鳟鱼中研究了温度对磺胺二甲嘧啶从药浴水中吸收速率和该药物消除速率的影响。温度从7℃升至14℃，使计算得出的吸收和消除速率常数增加了一倍多。在14℃时的生物半衰期（t）和达到稳态90%所需的时间（t）约为7℃时的一半。

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本文引用的文献

1

Plasma and tissue levels of trimethoprim in the rainbow trout, Salmo gairdneri, after absorption from fresh and salt water.虹鳟鱼（Salmo gairdneri）从淡水和盐水中吸收后，其血浆和组织中甲氧苄啶的水平。

Acta Vet Scand. 1980;21(1):18-25. doi: 10.1186/BF03546896.

2

Temperature influence on chemical toxicity to aquatic organisms.温度对水生生物化学毒性的影响。

J Water Pollut Control Fed. 1975 Feb;47(2):267-80.

3

Temperature and surfactant dependence of accumulation of 4-aminoantipyrine and ethanol in fish.鱼类中4-氨基安替比林和乙醇积累的温度及表面活性剂依赖性

J Pharm Sci. 1978 Nov;67(11):1558-63. doi: 10.1002/jps.2600671117.

4

Absorption from water as an alternative method for the administration of sulphonamides to rainbow trout, salmo gairdneri. The significance of the pKa value of the sulphonamides and the pH and salt content of the water.作为向虹鳟鱼（Salmo gairdneri）投喂磺胺类药物的替代方法，通过水进行吸收。磺胺类药物的pKa值以及水的pH值和盐含量的重要性。

Acta Vet Scand. 1978;19(1):102-9. doi: 10.1186/BF03547646.

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