虹鳟鱼（Salmo gairdneri）从淡水和盐水中吸收后，其血浆和组织中甲氧苄啶的水平。
Plasma and tissue levels of trimethoprim in the rainbow trout, Salmo gairdneri, after absorption from fresh and salt water.
作者信息
Bergsjø T, Søgnen E
出版信息
Acta Vet Scand. 1980;21(1):18-25. doi: 10.1186/BF03546896.
Abstract
This is a comparative study of uptake of trimethoprim from 1) fresh water, 2) salt water after 7 days of adaption and 3) salt water without previous adaptation. The rate and extent of absorption were found to vary significantly. The salt water adapted group reached a plasma concentration of approx. 1 µg/ml after 10 h, the unadapted salt water group after 24 to 48 h and the fresh water group did not reach this concentration. The results are discussed in relation to the non-ionic diffusion theory and to the alterations taking place in euryhaline species of fish during adaptation to salt water.
摘要
这是一项关于甲氧苄啶摄取情况的比较研究，研究对象包括：1）淡水环境中的鱼；2）适应7天后盐水环境中的鱼；3）未经预先适应的盐水环境中的鱼。结果发现，吸收速率和吸收程度存在显著差异。适应盐水环境的鱼群在10小时后血浆浓度达到约1微克/毫升，未适应盐水环境的鱼群在24至48小时后达到该浓度，而淡水环境中的鱼群未达到此浓度。结合非离子扩散理论以及广盐性鱼类在适应盐水环境过程中发生的变化对研究结果进行了讨论。
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J Exp Biol. 1963 Jun;40:335-41. doi: 10.1242/jeb.40.2.335.
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J Pharmacol Exp Ther. 1957 Mar;119(3):361-9.
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