作为向虹鳟鱼（Salmo gairdneri）投喂磺胺类药物的替代方法，通过水进行吸收。磺胺类药物的pKa值以及水的pH值和盐含量的重要性。
Absorption from water as an alternative method for the administration of sulphonamides to rainbow trout, salmo gairdneri. The significance of the pKa value of the sulphonamides and the pH and salt content of the water.
作者信息
Bergsjø T, Bergsjø T H
出版信息
Acta Vet Scand. 1978;19(1):102-9. doi: 10.1186/BF03547646.
Abstract
The effect of variations in pH and salt concentration on the absorption by rainbow trout of sulphonamides from water was investigated. Two trials were carried out: 1) Absorption from fresh water of sulphanilamide (pKa 10.4) and sulphadimidine (pKa 7.4) at pH 4, 6, 8 and 10 over a period of 96 hrs., and 2) Absorption from fresh water and sea water (salinity approx. 31 ‰) of the same two sulphonamides at pH 6 and 8 over a period of 24 hrs. The degree of acetylation of the two sulphonamides in rainbow trout was investigated.
摘要
研究了pH值和盐浓度变化对虹鳟鱼从水中吸收磺胺类药物的影响。进行了两项试验：1）在pH值为4、6、8和10的条件下，虹鳟鱼在96小时内从淡水中吸收磺胺（pKa 10.4）和磺胺二甲嘧啶（pKa 7.4）；2）在pH值为6和8的条件下，虹鳟鱼在24小时内从淡水和海水（盐度约为31‰）中吸收相同的两种磺胺类药物。研究了虹鳟鱼体内这两种磺胺类药物的乙酰化程度。
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