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卵巢上皮癌的一项流行病学研究。

An epidemiologic study of epithelial carcinoma of the ovary.

作者信息

Hildreth N G, Kelsey J L, LiVolsi V A, Fischer D B, Holford T R, Mostow E D, Schwartz P E, White C

出版信息

Am J Epidemiol. 1981 Sep;114(3):398-405. doi: 10.1093/oxfordjournals.aje.a113207.

Abstract

A case-control study to identify risk factors for epithelial ovarian cancer was undertaken among women in the age group 45-74 years who had been admitted to seven hospitals in Connecticut between July, 1977, and March, 1979. Characteristics that were found to increase the risk of epithelial ovarian cancer included being white, never having been pregnant, having a late age at menopause, having a family history of cancer of the ovary or endometrium, and having a long estimated number of years of ovulation. Prior use of post-menopausal estrogens did not alter the risk for epithelial ovarian cancer, but there was some indication that oral contraceptives protect against ovarian cancer. Women with ovarian cancer were somewhat more likely to have had a history of an underactive thyroid and were somewhat less likely to have had a history of an overactive thyroid than controls, although these trends were not statistically significant.

摘要

1977年7月至1979年3月期间,在康涅狄格州七家医院收治的45 - 74岁女性中开展了一项病例对照研究,以确定上皮性卵巢癌的危险因素。发现增加上皮性卵巢癌风险的特征包括:为白人、从未怀孕、绝经年龄较晚、有卵巢癌或子宫内膜癌家族史以及预计排卵年数较长。绝经后雌激素的既往使用情况并未改变上皮性卵巢癌的风险,但有一些迹象表明口服避孕药可预防卵巢癌。与对照组相比,卵巢癌患者患甲状腺功能减退症的病史略多,患甲状腺功能亢进症的病史略少,尽管这些趋势在统计学上并不显著。

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