Stiles M L
Am J Hosp Pharm. 1981 Nov;38(11):1743-5.
The effect of microwave radiation on the stability of frozen cefoxitin sodium solutions was investigated. The i.v. fluids used as vehicles for the 1-g admixtures of cefoxitin sodium were 5% dextrose injection and 0.9% sodium chloride injection in 50-ml and 100-ml polyvinyl chloride flexible containers. The antibiotic small-volume parenteral solutions were frozen at -20 degrees C for 72 hours and thawed by microwave radiation. Before and after the freeze-thaw process, the solutions were observed for changes in appearance with a light and dark field visual surveillance technique. In addition, pH determinations were made with a microprocessor ionanalyzer, and high-performance liquid chromatographic determinations of concentration were performed. No significant drug concentration changes were detected and no visible changes were observed. The pH changes were minimal. Microwave radiation can reduce thawing time of antibiotic admixtures. In this study, the stability of cefoxitin sodium solutions was not affected by the freeze-thaw process.
研究了微波辐射对头孢西丁钠冷冻溶液稳定性的影响。用于1g头孢西丁钠混合液的静脉输液载体为50ml和100ml聚氯乙烯软袋中的5%葡萄糖注射液和0.9%氯化钠注射液。抗生素小容量胃肠外营养液在-20℃冷冻72小时后用微波辐射解冻。在冻融过程前后，采用明场和暗场视觉监测技术观察溶液外观变化。此外，用微处理器离子分析仪测定pH值，并用高效液相色谱法测定浓度。未检测到药物浓度有显著变化，也未观察到明显变化。pH值变化极小。微波辐射可缩短抗生素混合液的解冻时间。在本研究中，头孢西丁钠溶液的稳定性不受冻融过程的影响。
