Wilson G, Stevenson R
Am J Optom Physiol Opt. 1981 Oct;58(10):797-802. doi: 10.1097/00006324-198110000-00003.
Halos indicate an important change in vision performance which can occur in contact lens wearers. Experimentally, halos occur when the cornea id deprived of atmospheric oxygen or bathed with hypotonic solutions. Pachometry is the accepted technique for measuring changes in the cornea, yet there is little evidence that measurement of overall corneal thickness is a sensitive indicator of structural changes in the epithelium, such as those causing halos. There is a need for a technique which is responsive to changes in the epithelium. This paper describes a new technique for quantifying changes in the epithelium by measuring halo brightness. Halos were produced by osmotic and anoxic stress, and recovery was monitored using measurements of corneal thickness and halo brightness. We found that the time course of halo recovery could be measured successfully on a naive subject. The technique provides information not available from pachometry and should be of considerable value in studies on the human cornea of factors which alter the optical integrity of the epithelium.
光晕表明视力表现发生了重要变化，这种情况可能出现在隐形眼镜佩戴者身上。在实验中，当角膜缺乏大气中的氧气或浸泡在低渗溶液中时，就会出现光晕。角膜厚度测量法是测量角膜变化的公认技术，但几乎没有证据表明测量角膜总厚度是上皮结构变化（如导致光晕的那些变化）的敏感指标。需要一种对上皮变化有反应的技术。本文描述了一种通过测量光晕亮度来量化上皮变化的新技术。通过渗透和缺氧应激产生光晕，并使用角膜厚度和光晕亮度测量来监测恢复情况。我们发现，在一个未经训练的受试者身上可以成功测量光晕恢复的时间进程。该技术提供了角膜厚度测量法无法获得的信息，在研究改变上皮光学完整性的因素对人角膜的影响方面应具有相当大的价值。
