Karayalcin G, Lanzkowsky P, Kari A B
Am J Pediatr Hematol Oncol. 1981 Summer;3(2):169-71. doi: 10.1097/00043426-198100320-00010.
Serum alpha-hydroxybutyrate dehydrogenase (alpha-HBDH) levels were determined in 28 children with homozygous sickle cell disease (SCD) during the steady state, crisis, and postcrisis periods. Serum alpha-HBDH levels were also studied in 20 patients with infection. In patients during the steady state, serum alpha-HBDH levels were significantly above control values. During the vaso-occlusive crisis there was a significant further increase in the alpha-HBDH levels. In patients with infection, however, there was no significant increase in serum alpha-HBDH levels. These findings clearly indicate that the level of serum alpha-HBDH in patients with SCD permits differentiation between vaso-occlusive crises, infection, and spurious symptoms.
在28名纯合子镰状细胞病（SCD）儿童的病情稳定期、危象期和危象后期测定了血清α-羟丁酸脱氢酶（α-HBDH）水平。还对20名感染患者的血清α-HBDH水平进行了研究。在病情稳定期的患者中，血清α-HBDH水平显著高于对照值。在血管闭塞性危象期间，α-HBDH水平进一步显著升高。然而，在感染患者中，血清α-HBDH水平没有显著升高。这些发现清楚地表明，SCD患者的血清α-HBDH水平有助于区分血管闭塞性危象、感染和假性症状。
