Kisker C T
Am J Pediatr Hematol Oncol. 1981 Summer;3(2):193-7. doi: 10.1097/00043426-198100320-00015.
Appropriate management of the bleeding newborn is easily accomplished by first assessing the clinical circumstances under which the bleeding occurs. Having determined the clinical circumstances, knowledge of the pathophysiology of disseminated intravascular coagulation, liver failure, vitamin K deficiency, and hemophilia coupled with knowledge of the normal levels of coagulation factor activities at birth leads to selection of appropriate laboratory tests to confirm the etiology of the bleeding. Once the etiology is confirmed, treatment requires management of associated clinical conditions and replacement of vitamin K and/or deficient coagulation factors.
通过首先评估新生儿出血发生的临床情况，即可轻松实现对出血新生儿的适当管理。确定临床情况后，了解弥散性血管内凝血、肝功能衰竭、维生素K缺乏症和血友病的病理生理学，再结合出生时凝血因子活性的正常水平，有助于选择适当的实验室检查以确认出血的病因。一旦病因得到确认，治疗需要处理相关的临床状况，并补充维生素K和/或缺乏的凝血因子。
