Karas S
Ann Emerg Med. 1981 Dec;10(12):627-30. doi: 10.1016/s0196-0644(81)80085-6.
To study the problem of drug interactions in an emergency department, a microcomputer was programmed to identify the potentially adverse enhancements and antagonistic interactions of drugs in a randomly chosen group of 355 patients who were currently taking or were administered two or more medications. Interactions were present in 57 patients (16%), with an incidence ranging from 5.6% for those taking two drugs to 100% for those taking seven drugs. From the total of 76 potential drug interactions identified, 69 involved one of only 10 drugs, and 15 interactions (20%) appeared to be potential clinical significant. To supplement the computer program and educational sessions, a common drug interaction table was developed, accounting for 90% of the potential drug interactions seen in our emergency department.
为研究急诊科的药物相互作用问题，我们编写了一个微型计算机程序，以识别在随机选取的355名正在服用或接受两种或更多药物治疗的患者群体中，药物潜在的不良增强和拮抗相互作用。57名患者（16%）存在相互作用，发生率从服用两种药物的患者的5.6%到服用七种药物的患者的100%不等。在总共识别出的76种潜在药物相互作用中，69种仅涉及10种药物中的一种，15种相互作用（20%）似乎具有潜在的临床意义。为补充计算机程序和教育课程，我们编制了一份常见药物相互作用表，涵盖了我们急诊科所见潜在药物相互作用的90%。
