Siim C, Lublin H K, Jensen H E
Ann Surg. 1981 Dec;194(6):687-91. doi: 10.1097/00000658-198112000-00004.
From 1964 to 1968 selective gastric vagotomy (SGV) and drainage was performed in 174 patients. Of these, 105 patients were followed-up 10-13 years after operation; 56 were dead. Ulcers recurred in 18 patients. The cumulated recurrence rate after 13 years (life table method) was 15% (95% confidence limits: 8-23). The method for drainage was usually either a Heineke-Mikulicz or a Finney pyloroplasty. There was a significantly higher risk of ulcer recurrence in the group that underwent Heineke-Mikulicz drainage procedures. The incidence of dumping and diarrhea had not changed during a five-year follow-up period. Two patients were slightly anemic. No patient was iron-deficient. Apart from two recurrent ulcers, gastroscopic examinations in 36 patients revealed no major changes, and biopsy specimens showed slight to moderate chronic atrophic gastritis in most cases. Visick grading showed 77% of the ulcers in Grade I + II, 19% in Grade VI. It is concluded that SGV has no place in the elective treatment of duodenal ulcer. Two alternatives are suggested.
1964年至1968年期间,对174例患者实施了选择性胃迷走神经切断术(SGV)及引流术。其中,105例患者在术后10至13年接受了随访;56例患者死亡。18例患者溃疡复发。采用寿命表法计算,13年后的累积复发率为15%(95%置信区间:8%-23%)。引流方法通常为海涅克-米库利奇(Heineke-Mikulicz)或芬尼(Finney)幽门成形术。接受海涅克-米库利奇引流术的患者组溃疡复发风险显著更高。在五年随访期内,倾倒综合征和腹泻的发生率未发生变化。两名患者有轻度贫血。无患者缺铁。除两例复发性溃疡外,36例患者的胃镜检查未发现重大变化,活检标本在大多数情况下显示为轻度至中度慢性萎缩性胃炎。维斯克(Visick)分级显示,77%的溃疡为I + II级,19%为III级。结论是,SGV在十二指肠溃疡的择期治疗中没有地位。提出了两种替代方案。