狗冠状动脉对乙酰水杨酸的收缩反应研究。
A study on constrictor response of dog coronary arteries to acetylsalicylic acid.
作者信息
Sakanashi M, Araki H, Furukawa T, Rokutanda M, Yonemura K
出版信息
Arch Int Pharmacodyn Ther. 1981 Jul;252(1):86-96.
The present study was designed to investigate the effects of acetylsalicylic acid at a high dose on dog coronary arteries. In the isolated and perfused dog hearts, an intracoronary injection of acetylsalicylic acid (10 mg) decreased coronary blood flow concomitant with diminution of myocardial contractile force, but did not change heart rate. In the isolated dog coronary arterial strips, acetylsalicylic acid (10-4 M) produced the contractions of them, which were significantly inhibited by calcium-free solution, diltiazem, nifedipine, phospholipase A2, arachidonate and prostaglandin E1. The results indicate that acetylsalicylic acid at a high dose produces coronary arterial contracture probably through inhibition of intravascular synthesis of vasodilating prostaglandins.
本研究旨在探讨高剂量乙酰水杨酸对犬冠状动脉的影响。在离体灌注犬心脏中，冠状动脉内注射乙酰水杨酸（10毫克）可使冠状动脉血流量减少，同时心肌收缩力减弱，但心率无变化。在离体犬冠状动脉条上，乙酰水杨酸（10-4 M）可使其收缩，无钙溶液、地尔硫䓬、硝苯地平、磷脂酶A2、花生四烯酸和前列腺素E1可显著抑制这种收缩。结果表明，高剂量乙酰水杨酸可能通过抑制血管内舒张性前列腺素的合成而导致冠状动脉挛缩。
Zotero 插件