Goldman M
Arch Int Pharmacodyn Ther. 1981 Aug;252(2):327-34.
A single dose of 100 mg/kg of commercially available 1, 1, 1,-trichloro-2, 2, bis (p-chlorophenyl), ethane, (DDT), dissolved in corn oil, was administrated to adult male Sprague-Dawley rats by stomach tube and two indices of thyroid function were examined. The iodide transport function of the thyroid gland determined by the thyroid: serum radioiodide concentration ration, (T:S) was depressed, and complete inhibition in thyroidal radioiodine release occurred 8 to 10 hr following administration of DDT and continued for 24 to 30 hr. Subsequently the block in thyroidal 131I release was followed by a return to a rate not significantly different from that of control rats. Whether the acute effects of a single large dose of DDT on thyroid function are a consequence of a local action on the thyroid gland or on pituitary thyrotropin release, or of some action elsewhere is not clear.
通过胃管给成年雄性斯普拉格-道利大鼠灌胃一剂溶解于玉米油中的市售1,1,1-三氯-2,2-双（对氯苯基）乙烷（滴滴涕），剂量为100毫克/千克，并检测了两项甲状腺功能指标。通过甲状腺：血清放射性碘浓度比（T:S）测定的甲状腺碘转运功能受到抑制，在给予滴滴涕后8至10小时甲状腺放射性碘释放完全被抑制，并持续24至30小时。随后，甲状腺131I释放的阻滞之后恢复到与对照大鼠无显著差异的速率。单次大剂量滴滴涕对甲状腺功能的急性影响是对甲状腺的局部作用、对垂体促甲状腺激素释放的作用，还是其他部位的某种作用，尚不清楚。
