Abreu L A, Abreu R R
Arch Geschwulstforsch. 1981;51(5):394-7.
High levels of serum ceruloplasmin oxidase activity were detected in U strain isogenic male rats bearing a syngeneic sarcoma in all phases of tumoral evolution. Normal levels of ceruloplasmin were only observed after a single i.p. dose of cyclophosphamide (100 mg/kg). However subsequent weekly administration of the drug did not prevent the return of hyperceruloplasminemia in the tumor hosts. Normal rats treated similarly with cyclophosphamide presented a fall in the enzyme activity after the 1st dose.
在携带同基因肉瘤的U系同基因雄性大鼠肿瘤发生发展的各个阶段，均检测到血清铜蓝蛋白氧化酶活性水平升高。仅在腹腔注射单次环磷酰胺（100 mg/kg）后观察到铜蓝蛋白水平正常。然而，随后每周给药并未阻止肿瘤宿主高铜蓝蛋白血症的复发。用环磷酰胺进行类似处理的正常大鼠在首次给药后酶活性下降。
