Berdinskikh N K, Voloshchenko Iu V, Livshits V I, Dolzhenko V P, Korol' D R
Eksp Onkol. 1984;6(3):63-6.
Exogenous ceruloplasmin influence on experimental tumour growth and intensity of normal and malignant cell proliferation in tissue culture was investigated. It was found that ceruloplasmin administration to animals with transplanted tumours caused a 25-50% inhibition of tumour growth. A growth inhibiting activity of ceruloplasmin observed in tissue culture at the concentration of 5 mg/ml was established. It is also shown that ceruloplasmin did not reduce the antitumour effect of cyclophosphamide.
研究了外源性铜蓝蛋白对实验性肿瘤生长以及组织培养中正常细胞和恶性细胞增殖强度的影响。发现给移植肿瘤的动物注射铜蓝蛋白可使肿瘤生长受到25% - 50%的抑制。已确定在组织培养中，浓度为5毫克/毫升时铜蓝蛋白具有生长抑制活性。还表明铜蓝蛋白不会降低环磷酰胺的抗肿瘤作用。
