Screening system for the evaluation of preparations with potential cytostatic and immunotropic activity. I. Derivatives of 4,5-dihydro-2h-pyridazinone-3.

New screening system for the evaluation of preparations with potential cytostatic and immunotropic activity has been suggested. It consists in their interaction in relation to the mitogenic activity of phytohemagglutinin. A group of preparations, derivatives of 4,5-dihydro-2H-pyridazinone-3 was evaluated. It appeared that among the examined compounds there were preparations suppressing or stimulating the incorporation of 14C-thymidine to lymphocyte nuclei. Dependence between chemical structure and pharmacological activity in this group of compounds is discussed.