Kowalczyk-Bronisz S H, Pomorski J, Bubak B, Pregiel M, Błaszczyk B
Department of Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Arch Immunol Ther Exp (Warsz). 1995;43(3-4):199-205.
It is presented that the newly synthesized mono- and disubstituted 2,5-dimercapto-1,3,4-thiodiazole derivatives exert immunotropic activity. This effect was evaluated by measuring plaque forming cell number, circulating immunoglobulins level, autologous rosette number, mitogenic activity and by performing popliteal lymph node assay. It is shown that intensity of immunotropic activity depends on chemical structure: mono-substituted derivatives had a strong suppressive effect, disubstituted compounds showed the variable activity. One compound of this group exerted a stimulatory effect. The tested compounds were active in popliteal lymph node assay and had no mitogenic activity.
结果表明，新合成的单取代和双取代2,5 - 二巯基 - 1,3,4 - 噻二唑衍生物具有免疫调节活性。通过测量空斑形成细胞数量、循环免疫球蛋白水平、自身花环数量、促有丝分裂活性以及进行腘窝淋巴结试验来评估这种作用。结果显示，免疫调节活性的强度取决于化学结构：单取代衍生物具有较强的抑制作用，双取代化合物表现出不同的活性。该组中的一种化合物具有刺激作用。所测试的化合物在腘窝淋巴结试验中具有活性，且无促有丝分裂活性。
