Jakobiec F A, Silbert G
Arch Ophthalmol. 1981 Dec;99(12):2117-32. doi: 10.1001/archopht.1981.03930020993002.
A retrospective clinicopathologic study of 189 iris and iris and ciliary body lesions originally diagnosed as melanomas led to a nine-part histopathologic classification. Eighty-seven percent of lesions were reassigned to six benign categories and 13% were assigned to three malignant ones (spindle-B and epithelioid cell melanomas). There were no tumor deaths. The benign lesions were so classified if the constituent cells displayed bland cytologic characteristics, even though they might have produced a surface plaque or growth onto the trabecular meshwork and peripheral cornea. No clinical features were found to distinguish the benign from malignant tumors, including diffuse spread and the presence of glaucoma. The six recurrent tumors were equally divided between benign and malignant lesions. Thirty-six of 42 patients with incompletely excised lesions did not show further clinical problems on follow-up, establishing the inherently benign nature of most of the tumors.
一项对189例最初诊断为黑色素瘤的虹膜及虹膜睫状体病变进行的回顾性临床病理研究，得出了一个九部分的组织病理学分类。87%的病变被重新归类为六个良性类别，13%被归类为三个恶性类别（梭形B细胞和上皮样细胞黑色素瘤）。无肿瘤死亡病例。如果组成细胞显示出温和的细胞学特征，即使它们可能已在小梁网和周边角膜上形成表面斑块或生长，这些良性病变也会如此分类。未发现能区分良性肿瘤与恶性肿瘤的临床特征，包括弥漫性扩散和青光眼的存在。6例复发性肿瘤在良性和恶性病变中各占一半。42例病变切除不完全的患者中，有36例在随访中未出现进一步的临床问题，证实了大多数肿瘤本质上是良性的。
