Kendig J J, Schneider T M, Cohen E N
J Appl Physiol Respir Environ Exerc Physiol. 1978 Nov;45(5):747-50. doi: 10.1152/jappl.1978.45.5.747.
Repetitive and spontaneous impulse generation appears in nerve axons exposed to high pressure. This phenomenon is a possible basis for high-pressure nervous syndrome (HPNS) or pressure reversal of anesthesia, two examples of an antagonistic interaction between anesthetic drugs and high pressure. In the present study, the interactions between three classes of anesthetic drug (ethyl alcohol, the volatile inhalation agent halothane, and phenobarbital) and repetitive activity were explored. Ethyl alcohol (5% in solution) and halothane (1.3 and 3.4% in oxygen) inhibited pressure-induced repetitive activity. Phenobarbital at 0.25 mM in solution, the maximum concentration obtainable at low temperature, was partially effective. The three drugs produce an unconscious state that is "reversed" at hyperbaric pressure. Halothane and phenobarbital inhibit HPNS, but ethyl alcohol has not been tested for this property. The results thus support a relevance of repetitive activity to HPNS, to pressure reversal of anesthesia, or to both.
暴露于高压下的神经轴突会出现重复性和自发性冲动产生。这种现象可能是高压神经综合征（HPNS）或麻醉压力逆转的基础，这是麻醉药物与高压之间拮抗相互作用的两个例子。在本研究中，探讨了三类麻醉药物（乙醇、挥发性吸入剂氟烷和苯巴比妥）与重复性活动之间的相互作用。乙醇（溶液中5%）和氟烷（氧气中1.3%和3.4%）抑制压力诱导的重复性活动。溶液中0.25 mM的苯巴比妥（低温下可获得的最大浓度）有部分效果。这三种药物会产生一种在高压下“逆转”的无意识状态。氟烷和苯巴比妥可抑制HPNS，但乙醇尚未对此特性进行测试。因此，结果支持重复性活动与HPNS、麻醉压力逆转或两者都有关联。
