Swanson G D, Whipp B J, Kaufman R D, Aqleh K A, Winter B, Bellville J W
J Appl Physiol Respir Environ Exerc Physiol. 1978 Dec;45(6):871-7. doi: 10.1152/jappl.1978.45.6.971.
Steplike end-tidal hypoxic drives (PETCO2 = 53 Torr) lasting for 5 min were generated in a group of normal subjects and a group of carotid body-resected subjects when end-tidal CO2 was maintained constant under eucapnic (PETCO2 = 39 Torr) and hypercapnic (PETCO2 = 49 Torr) conditions. The hypoxic ventilatory response of the normal subjects was prompt and significant in eucapnia and was enhanced in the hypercapnic state, evidencing CO2-O2 interaction. In contrast, the carotid body-resected subjects did not respond to eucapnic hypoxia but did demonstrate a small but significant ventilatory response to hypoxia against the hypercapnic background. This suggests that the aortic bodies in man may contribute a small component of the hypoxic ventilatory drive under hypercapnic conditions, although the possibility of neuromalike ending regeneration cannot be excluded.
在一组正常受试者和一组切除颈动脉体的受试者中，当在等碳酸血症（呼气末二氧化碳分压 = 39 Torr）和高碳酸血症（呼气末二氧化碳分压 = 49 Torr）条件下使呼气末二氧化碳保持恒定时，产生了持续5分钟的阶梯式呼气末低氧驱动（呼气末二氧化碳分压 = 53 Torr）。正常受试者在等碳酸血症时的低氧通气反应迅速且显著，在高碳酸血症状态下增强，表明存在二氧化碳 - 氧气相互作用。相比之下，切除颈动脉体的受试者对等碳酸血症性低氧无反应，但在高碳酸血症背景下对低氧表现出小但显著的通气反应。这表明，尽管不能排除神经样末梢再生的可能性，但人类的主动脉体在高碳酸血症条件下可能对低氧通气驱动有一小部分贡献。
