葡萄糖对饥饿大鼠肝细胞中由丙氨酸或乳酸合成碳水化合物的影响。
Effect of glucose on carbohydrate synthesis from alanine or lactate in hepatocytes from starved rats.
作者信息
Solanki K, Nyfeler F, Moser U K, Walter P
出版信息
Biochem J. 1980 Oct 15;192(1):377-80. doi: 10.1042/bj1920377.
Abstract
In hepatocytes from starved rats, 10mM-glucose suppressed in incorporation of 2mM labelled alanine into glucose+glycogen by more than 40%, whereas no inhibition was observed with labelled lactate as substrate. Addition of glycerol instead of glucose did not show this inhibition. The inhibitory effect could also be demonstrated in label-free experiments.
摘要
在饥饿大鼠的肝细胞中，10mM葡萄糖使2mM标记丙氨酸掺入葡萄糖+糖原的量减少了40%以上，而以标记乳酸为底物时未观察到抑制作用。用甘油代替葡萄糖添加并未显示出这种抑制作用。在无标记实验中也能证明这种抑制作用。
相似文献
1
Effect of glucose on carbohydrate synthesis from alanine or lactate in hepatocytes from starved rats.葡萄糖对饥饿大鼠肝细胞中由丙氨酸或乳酸合成碳水化合物的影响。
Biochem J. 1980 Oct 15;192(1):377-80. doi: 10.1042/bj1920377.
2
Restoration of glycogenesis in hepatocytes from starved rats.饥饿大鼠肝细胞中糖原生成的恢复。
Life Sci. 1977 Mar 15;20(6):1027-34. doi: 10.1016/0024-3205(77)90290-9.
3
Carbohydrate metabolism of the perfused rat liver.灌注大鼠肝脏的碳水化合物代谢
Biochem J. 1967 Nov;105(2):869-75. doi: 10.1042/bj1050869.
4
Stimulation by glucose of gluconeogenesis in hepatocytes isolated from starved rats.饥饿大鼠分离的肝细胞中葡萄糖对糖异生的刺激作用。
Biochem J. 1987 Aug 1;245(3):661-8. doi: 10.1042/bj2450661.
5
Glutamine is a good substrate for glycogen synthesis in isolated hepatocytes from 72 h-starved rats, but not from 24 h- or 48 h-starved rats.谷氨酰胺是72小时饥饿大鼠分离肝细胞中糖原合成的良好底物，但不是24小时或48小时饥饿大鼠的良好底物。
Biochem J. 1992 Dec 15;288 ( Pt 3)(Pt 3):795-9. doi: 10.1042/bj2880795.
6
Lactate production and absence of gluconeogenesis from placental transferred substrates in fetuses from fed and 48-H starved rats.来自进食及饥饿48小时大鼠的胎儿中，胎盘转运底物的乳酸生成及糖异生缺失情况
Pediatr Res. 1987 Jul;22(1):6-10. doi: 10.1203/00006450-198707000-00002.
7
The effects of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) on glycolysis and biosynthetic processes of the isolated perfused rat liver.氟烷（2-溴-2-氯-1,1,1-三氟乙烷）对离体灌注大鼠肝脏糖酵解及生物合成过程的影响。
Biochem J. 1972 Jul;128(3):711-20. doi: 10.1042/bj1280711.
8
Lactate production in the perfused rat liver.灌注大鼠肝脏中的乳酸生成
Biochem J. 1971 Nov;125(1):129-39. doi: 10.1042/bj1250129.
9
10
Role of fructose 2,6-bisphosphate in the control by glucagon of gluconeogenesis from various precursors in isolated rat hepatocytes.果糖2,6 -二磷酸在胰高血糖素对离体大鼠肝细胞中各种前体物质糖异生的调控作用。
Biochem J. 1984 Feb 15;218(1):165-70. doi: 10.1042/bj2180165.
引用本文的文献
1
Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation.Sirt1 蛋白介导的去乙酰化作用调节糖酵解酶磷酸甘油酸变位酶-1。
J Biol Chem. 2012 Feb 3;287(6):3850-8. doi: 10.1074/jbc.M111.317404. Epub 2011 Dec 7.
2
Stimulation by glucose of gluconeogenesis in hepatocytes isolated from starved rats.饥饿大鼠分离的肝细胞中葡萄糖对糖异生的刺激作用。
Biochem J. 1987 Aug 1;245(3):661-8. doi: 10.1042/bj2450661.
本文引用的文献
1
Effect of epinephrine on rat diaphragm.肾上腺素对大鼠膈肌的作用。
J Biol Chem. 1950 Dec;187(2):769-76.
2
Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats.肝脏中糖异生的调控。I. 大鼠灌注肝脏中糖异生的一般特征。
J Biol Chem. 1967 Jun 10;242(11):2622-36.
3
Removal of fatty acids from serum albumin by charcoal treatment.通过活性炭处理从血清白蛋白中去除脂肪酸。
J Biol Chem. 1967 Jan 25;242(2):173-81.
4
Glucose regulation of hepatic gluconeogenesis.肝脏糖异生的葡萄糖调节
Am J Physiol. 1968 Jun;214(6):1346-51. doi: 10.1152/ajplegacy.1968.214.6.1346.
5
Correlated morphometric and biochemical studies on the liver cell. I. Morphometric model, stereologic methods, and normal morphometric data for rat liver.肝细胞的形态计量学与生物化学相关研究。I. 大鼠肝脏的形态计量学模型、体视学方法及正常形态计量学数据。
J Cell Biol. 1969 Jul;42(1):68-91. doi: 10.1083/jcb.42.1.68.
6
Binucleation in mammalian liver. Studies on the control of cytokinesis in vivo.哺乳动物肝脏中的双核化。体内胞质分裂控制的研究。
Exp Cell Res. 1972 Oct;74(2):455-65. doi: 10.1016/0014-4827(72)90401-6.
7
Stimulation by glucagon of the incorporation of U-14C-labeled substrates into glucose by isolated hepatocytes from fed rats.
Biochim Biophys Acta. 1975 Sep 8;404(1):110-23. doi: 10.1016/0304-4165(75)90152-x.
8
Effect of lithium on glycogen synthesis in hepatocytes from rat liver.锂对大鼠肝脏肝细胞中糖原合成的影响。
FEBS Lett. 1979 Dec 1;108(1):197-9. doi: 10.1016/0014-5793(79)81209-0.
9
Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated hepatocytes.离体肝细胞中丙酮酸激酶活性及糖异生的激素调控。
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2762-6. doi: 10.1073/pnas.73.8.2762.
Zotero 插件