葡萄糖对饥饿大鼠肝细胞中由丙氨酸或乳酸合成碳水化合物的影响。
Effect of glucose on carbohydrate synthesis from alanine or lactate in hepatocytes from starved rats.
作者信息
Solanki K, Nyfeler F, Moser U K, Walter P
出版信息
Biochem J. 1980 Oct 15;192(1):377-80. doi: 10.1042/bj1920377.
Abstract
In hepatocytes from starved rats, 10mM-glucose suppressed in incorporation of 2mM labelled alanine into glucose+glycogen by more than 40%, whereas no inhibition was observed with labelled lactate as substrate. Addition of glycerol instead of glucose did not show this inhibition. The inhibitory effect could also be demonstrated in label-free experiments.
摘要
在饥饿大鼠的肝细胞中，10mM葡萄糖使2mM标记丙氨酸掺入葡萄糖+糖原的量减少了40%以上，而以标记乳酸为底物时未观察到抑制作用。用甘油代替葡萄糖添加并未显示出这种抑制作用。在无标记实验中也能证明这种抑制作用。
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