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非电离辐射对大鼠小脑浦肯野细胞的影响。

Effect of nonionizing radiation on the Purkinje cells of the rat cerebellum.

作者信息

Albert E N, Sherif M F, Papadopoulos N J, Slaby F J, Monahan J

出版信息

Bioelectromagnetics. 1981;2(3):247-57. doi: 10.1002/bem.2250020306.

DOI:10.1002/bem.2250020306
PMID:7306221
Abstract

In one experiment, Sprague Dawley rats (16-21 days of gestation) and their offspring were exposed to 100-MHz (CW) electromagnetic radiation at 46 mW/cm2 (SAR 2.77 mW/g) for 4 h/day for 97 days. In another experiment, the pregnant rats were irradiated daily from 17 to 21 days of gestation with 2450-MHz (CW) microwaves at 10 mW/cm2 (SAR 2 m W/G) for 21 h/day. In a third experiment, 6-day old rat pups were irradiated 7 h/day for five days with 2450-MHz radiation at 10 mW/cm2. Equal numbers of animals were sham irradiated in each group. Quantitative studies of Purkinje cells showed a significant and irreversible decrease in rats irradiated during fetal or fetal and early postnatal life. In animals exposed postnatally, and euthanized immediately after irradiation, significant decrease in the relative number of Purkinje cells was apparent. However, restoration apparently occurred after forty days of recovery.

摘要

在一项实验中,将妊娠16 - 21天的斯普拉格 - 道利大鼠及其后代暴露于频率为100兆赫兹(连续波)、功率密度为46毫瓦/平方厘米(比吸收率为2.77毫瓦/克)的电磁辐射下,每天照射4小时,持续97天。在另一项实验中,妊娠17至21天的怀孕大鼠每天接受频率为2450兆赫兹(连续波)、功率密度为10毫瓦/平方厘米(比吸收率为2毫瓦/克)的微波照射,每天照射21小时。在第三项实验中,对6日龄的幼鼠进行为期五天、每天7小时的2450兆赫兹、功率密度为10毫瓦/平方厘米的辐射照射。每组均有相同数量的动物接受假照射。对浦肯野细胞的定量研究表明,在胎儿期或胎儿期及出生后早期接受照射的大鼠中,浦肯野细胞数量出现了显著且不可逆的减少。在出生后接受照射并在照射后立即安乐死的动物中,浦肯野细胞的相对数量明显减少。然而,在恢复40天后,数量明显恢复。

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