铅对尿酸盐成核的影响。

The effect of lead upon urate nucleation.

作者信息

Tak H K, Wilcox W R, Cooper S M

出版信息

Arthritis Rheum. 1981 Oct;24(10):1291-5. doi: 10.1002/art.1780241009.

Abstract

Lead urate was crystallized from solutions originally containing 0.595 mM (10 mg%) urate and 0.297 mM PbCl2. In the absence of lead, monosodium urate does not nucleate unless the urate concentration exceeds 80 mg%. Lead urate crystals were negatively birefringent and had a distinct x-ray powder diffraction pattern. Crystals of monosodium urate nucleated on lead urate seed crystals when the urate concentration was 10 mg%. These studies indicate that with physiologic conditions of temperature, pH, and ionic strength, spontaneous nucleation of lead urate can be demonstrated.

摘要

尿酸铅从最初含有0.595 mM（10 mg%）尿酸盐和0.297 mM氯化铅的溶液中结晶出来。在没有铅的情况下，除非尿酸盐浓度超过80 mg%，尿酸单钠不会成核。尿酸铅晶体具有负双折射性，并有独特的X射线粉末衍射图谱。当尿酸盐浓度为10 mg%时，尿酸单钠晶体在尿酸铅籽晶上成核。这些研究表明，在温度、pH值和离子强度的生理条件下，可以证明尿酸铅的自发成核。