Pak C Y, Arnold L H
Proc Soc Exp Biol Med. 1975 Sep;149(4):930-2. doi: 10.3181/00379727-149-38929.
Seeds of monosodium urate caused heterogeneous nucleation of calcium oxalate at pH 5.7 and 6.7, and of calcium phosphate at pH 5.3, 5.7, and 6.7 from metastably supersaturated solutions in vitro. Seeds of uric acid had a small or no effect. The results could account for the formation of calcium stones among patients with hyperuricosuria and normocalciuria.
尿酸钠晶种在体外pH值为5.7和6.7时可引发草酸钙的异相成核，在pH值为5.3、5.7和6.7时可引发磷酸钙的异相成核，这些晶种来自亚稳态过饱和溶液。尿酸晶种的影响很小或没有影响。这些结果可以解释高尿酸尿症和正常钙尿症患者中钙结石的形成。
