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[人类胶质母细胞瘤免疫学研究中的体外细胞毒性]

[In vitro cytotoxicity in the immunological study of human glioblastomas].

作者信息

Parente R, Bucci Sabattini M A, Servadei F

出版信息

Boll Soc Ital Biol Sper. 1981 Aug 15;57(15):1635-41.

PMID:7306407
Abstract

An immunological study about the lymphocytes of nineteen patients affected by glioblastoma has been executed by using CML and ADCC tests. Eleven healthy subjects and nine ones affected by bladder carcinoma have been studied for control. The CML test has demonstrated an increase of citotoxic activity of lymphocytes in the totality of the patients affected by glioblastoma (37,09 +/- 3,67)% versus (4,00 +/- 1,78)% of controls. The ADCC test has demonstrated diminution of citotoxic activity of lymphocytes of the patients affected by glioblastoma in comparison with controls (20,57 +/- 9,77)% versus (29,18 +/- 6,67)% of the healthy controls versus (27,66 +/- 8,51)% of bearers of bladder carcinomas.

摘要

通过使用CML和ADCC测试,对19例胶质母细胞瘤患者的淋巴细胞进行了一项免疫学研究。研究了11名健康受试者和9名膀胱癌患者作为对照。CML测试表明,胶质母细胞瘤患者淋巴细胞的细胞毒性活性增加,为(37.09±3.67)%,而对照组为(4.00±1.78)%。ADCC测试表明,与对照组相比,胶质母细胞瘤患者淋巴细胞的细胞毒性活性降低,健康对照组为(29.18±6.67)%,胶质母细胞瘤患者为(20.57±9.77)%,膀胱癌患者为(27.66±8.51)%。

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