毛细胞白血病中的中性糖鞘脂
Neutral glycosphingolipids in hairy cell leukemia.
作者信息
Lee W M, Klock J C, Macher B A
出版信息
Biochemistry. 1981 Oct 27;20(22):6505-8. doi: 10.1021/bi00525a032.
The neutral glycosphingolipids of hairy cells from a patient with hairy cell leukemia were chemically analyzed by thin-layer and gas-liquid chromatography, mass spectrometry, combined gas chromatography-mass spectrometry, and glycosidase treatment. These cells were found to have compounds containing one to four sugars with the following structures: Glc1 leads to 1Cer Gal beta 1 leads to 4Glc1 leads to 1Cer Gal alpha 1 leads to 4 Gal beta 1 leads to 4Glc1 leads to 1Cer GalNAc beta 1 leads to 3Gal alpha 1 leads to 4Gal beta 1 leads to 4Glc1 leads to 1Cer These compounds belong to the globo series of neutral glycosphingolipids and are similar to those found in human lymphocytes and chronic lymphocytic leukemia cells. They differ from the neutral glycosphingolipids found in human neutrophils and chronic myelogenous leukemia cells which are of the lactoneo and gala type. Neutral glycosphingolipids may be useful in classifying leukemias of uncertain origin.
运用薄层色谱法、气液色谱法、质谱分析法、气相色谱 - 质谱联用分析法以及糖苷酶处理法，对一名毛细胞白血病患者的毛细胞中的中性糖鞘脂进行了化学分析。结果发现，这些细胞含有含一至四个糖的化合物，其结构如下：Glc1→1Cer、Galβ1→4Glc1→1Cer、Galα1→4Galβ1→4Glc1→1Cer、GalNAcβ1→3Galα1→4Galβ1→4Glc1→1Cer。这些化合物属于中性糖鞘脂的球系列，与在人类淋巴细胞和慢性淋巴细胞白血病细胞中发现的化合物相似。它们与在人类中性粒细胞和慢性粒细胞白血病细胞中发现的内酯型和加拉型中性糖鞘脂不同。中性糖鞘脂可能有助于对来源不明的白血病进行分类。
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