在美国药典中，用正庚烷替代乙醚用于盐酸氯丙嗪片剂、注射剂和糖浆剂的含量测定。
Substitution of n-heptane for ethyl ether in USP assay for chlorpromazine hydrochloride in tablets, injections, and sirups.
作者信息
Kirchhoefer R D, Myrick J W
出版信息
J Assoc Off Anal Chem. 1978 Nov;61(6):1519-20.
PMID:730658
Abstract
Peroxide levels above 0.0001% in the ethyl ether used in the USP XIX assay for chlorpromazine hydrochloride in tablets, sirups, and injections produce a distorted spectrophotometric curve in the 350--220 nm region. The use of peroxide-free ethyl ether or n-heptane avoids this problem. Recoveries of 91-100% are obtained with either of these reagents.
摘要
美国药典第十九版中用于片剂、糖浆剂和注射剂中盐酸氯丙嗪含量测定的乙醚中，过氧化物含量超过0.0001%时，会在350 - 220纳米区域产生扭曲的分光光度曲线。使用无过氧化物的乙醚或正庚烷可避免此问题。使用这两种试剂中的任何一种，回收率均为91% - 100%。
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