Deschavanne P J, Guichard M, Malaise E P
Br J Radiol. 1981 Nov;54(647):973-7. doi: 10.1259/0007-1285-54-647-973.
The repair of radiation damage has been measured in mouse lung using an in vitro colony assay. Following a single dose of 10.5 Gy delivered to the lung in vivo, we observed, six hours after irradiation, an increase of the fraction of surviving cells, which did not change further between six and 24 hours (repair of potentially lethal damage). A similar observation was made using a split-dose method (repair of sublethal damage). The extent of radiation repair is comparable with that of other rodent cells irradiated in vivo. The significance of these results is discussed in relation to the late effects observed following irradiation of lung tissue.
已使用体外集落测定法在小鼠肺部测量了辐射损伤的修复情况。在体内对肺部给予单次10.5 Gy剂量照射后，我们观察到，照射后6小时，存活细胞分数增加，在6至24小时之间没有进一步变化（潜在致死性损伤的修复）。使用分次剂量法（亚致死性损伤的修复）也得到了类似的观察结果。辐射修复的程度与体内照射的其他啮齿动物细胞相当。结合肺部组织照射后观察到的晚期效应讨论了这些结果的意义。
