星形细胞瘤（C6）细胞提取物中的胶质细胞生长促进因子。

Glial cell growth-promoting factor in astrocytoma (C6) cell extracts.

作者信息

Kato T, Yamakawa Y, Sakazaki Y, Ito J, Kato H, Tsunooka H, Masaoka A, Tanaka R

出版信息

Brain Res. 1981 Nov;254(4):596-601. doi: 10.1016/0165-3806(81)90028-6.

Abstract

The presence of glia maturation factor (GMF)-like activity was demonstrated in rat astrocytoma cells (C6 cells). The extracts of C6 cells enhanced the DNA synthesis of cultured glioblasts 3-fold at the maximum, inducing such morphological changes as extrusion of processes. C6 cells also showed a proliferative response to the extracts, though the responsiveness in terms of effective concentration of C6 extracts was about a half of the glioblast responsiveness. The extracts lowered growth rate of neuroblastoma cells and especially decreased their DNA synthesis without a morphological differentiation.

摘要

在大鼠星形细胞瘤细胞（C6细胞）中证实存在胶质细胞成熟因子（GMF）样活性。C6细胞提取物能使培养的成胶质细胞的DNA合成最多增强3倍，诱导出诸如突起伸出等形态变化。C6细胞对提取物也表现出增殖反应，不过就C6提取物的有效浓度而言，其反应性约为成胶质细胞反应性的一半。提取物降低了神经母细胞瘤细胞的生长速率，尤其减少了其DNA合成，且未出现形态分化。