亚硝基甲基十二烷基胺对欧洲仓鼠的致癌作用。

The carcinogenic effect of nitrosomethyldodecylamine in European hamsters.

作者信息

Ketkar M B, Althoff J, Lijinsky W

出版信息

Cancer Lett. 1981 Jul;13(2):165-8. doi: 10.1016/0304-3835(81)90144-0.

Abstract

Laboratory-bred European hamsters received nitrosomethyldodecylamine (NMDA) subcutaneously in olive oil once weekly for life. The animals showed mainly mucoepidermoid carcinomas of the lung, carcinomas of the urinary bladder and squamous cell carcinomas and sarcomas at the injection site. The tumour incidence was 90% in males and 70% in females, while the average tumour latency was 32 +/- 6 weeks for both sexes. Males had an average survival time of 29 +/- 17 weeks and females 24 +/- 19 weeks.

摘要

在实验室饲养的欧洲仓鼠，每周一次皮下注射溶于橄榄油的亚硝基甲基十二烷基胺（NMDA），直至其死亡。这些动物主要出现肺部黏液表皮样癌、膀胱癌、注射部位的鳞状细胞癌和肉瘤。雄性动物的肿瘤发生率为90%，雌性为70%，而两性的平均肿瘤潜伏期均为32±6周。雄性动物的平均存活时间为29±17周，雌性为24±19周。