The carcinogenic effect of nitrosomethyldodecylamine in European hamsters.
作者信息
Ketkar M B, Althoff J, Lijinsky W
出版信息
Cancer Lett. 1981 Jul;13(2):165-8. doi: 10.1016/0304-3835(81)90144-0.
PMID:7306954
Abstract
Laboratory-bred European hamsters received nitrosomethyldodecylamine (NMDA) subcutaneously in olive oil once weekly for life. The animals showed mainly mucoepidermoid carcinomas of the lung, carcinomas of the urinary bladder and squamous cell carcinomas and sarcomas at the injection site. The tumour incidence was 90% in males and 70% in females, while the average tumour latency was 32 +/- 6 weeks for both sexes. Males had an average survival time of 29 +/- 17 weeks and females 24 +/- 19 weeks.
摘要
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