N-甲基-N'-硝基-N-亚硝基胍（MNNG）对欧洲仓鼠的致癌作用。
Carcinogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in European hamsters.
作者信息
Ketkar M, Reznik G, Green U
出版信息
Cancer Lett. 1978 Apr;4(4):241-4. doi: 10.1016/s0304-3835(78)94842-5.
PMID:647665
Abstract
Laboratory-bred European hamsters received intragastric administrations of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) once weekly for 20 weeks. The animals showed mainly squamous cell papillomas and carcinomas of the fore-stomach. The tumour incidence was higher in males (80%) than in females (30%). The average tumour latency was comparatively short (25 weeks).
摘要
实验室饲养的欧洲仓鼠每周接受一次N-甲基-N'-硝基-N-亚硝基胍（MNNG）灌胃，持续20周。这些动物主要出现前胃鳞状细胞乳头状瘤和癌。雄性动物的肿瘤发生率（80%）高于雌性动物（30%）。平均肿瘤潜伏期相对较短（25周）。
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