Morrow P E
Chest. 1981 Dec;80(6 Suppl):809-13. doi: 10.1378/chest.80.6.809.
Designing a therapeutic aerosol on the basis of its physical properties is a very important objective, but experience has also clearly demonstrated the value of controlling the breathing and drug administration patterns. Presently, the state of aerosol technology is well advanced of its use in medicine. The employment of more sophisticated aerosolization methods can undoubtedly be advocated on both intuitive and scientific grounds, but whether the benefit will justify their cost and complexities is far less evident. This report attempts to set the issue in perspective by reviewing the important properties of commonly-prepared heterodisperse aerosols with monodisperse aerosols of the research laboratory in the context of bronchial deposition and retention.
基于其物理性质设计治疗性气雾剂是一个非常重要的目标，但经验也清楚地证明了控制呼吸和药物给药模式的价值。目前，气雾剂技术在医学上的应用已经相当先进。毫无疑问，从直观和科学的角度都可以提倡采用更复杂的雾化方法，但这种方法的益处是否能证明其成本和复杂性是合理的，就远不那么明显了。本报告试图通过在支气管沉积和滞留的背景下，将常用制备的多分散气雾剂与研究实验室的单分散气雾剂的重要特性进行对比，来正确看待这个问题。
