Weich D J, Viljoen H, Sweetlove M A, Pretorius P H, van Rensburg A J, Lötter M G, Minnaar P C, Otto A C
Department of Internal Medicine, University of the Orange Free State, Bloemfontein, South Africa.
Eur J Nucl Med. 1988;14(11):533-7. doi: 10.1007/BF00286771.
We investigated the effect of Fenoterol, a selective beta 2 adrenoceptor stimulant, on mucociliary clearance in 12 patients with chronic bronchitis. Mucociliary clearance was measured with a scintillation camera after inhalation of a 99mTc labelled aerosol. Fenoterol was administered one h after acquisition commenced and imaging was maintained for a further two h. Three regions of interest (ROI) were selected over each lung to generate time activity curves. Corrections for decay, alveolar deposition (using 24 h image), cough and movement of activity through each ROI were carried out. An exponential function was fitted to the clearance curves to determine clearance rates. The increase in percentage clearance after Fenoterol administration for the left and right whole lung ROI was 35% and 36% per h respectively (P = 0.006 and 0.020). Fenoterol enhances cilial clearance in chronic bronchitis patients.
我们研究了选择性β2肾上腺素能受体激动剂非诺特罗对12例慢性支气管炎患者黏液纤毛清除功能的影响。吸入99mTc标记的气雾剂后，用闪烁照相机测量黏液纤毛清除功能。采集开始1小时后给予非诺特罗，并继续成像2小时。在每侧肺上选择三个感兴趣区（ROI）以生成时间-活性曲线。对衰变、肺泡沉积（使用24小时图像）、咳嗽以及活性物质通过每个ROI的移动进行校正。将指数函数拟合到清除曲线以确定清除率。给予非诺特罗后，左、右全肺ROI的清除率每小时分别增加35%和36%（P = 0.006和0.020）。非诺特罗可增强慢性支气管炎患者的纤毛清除功能。
