甲氧苯丙胺及其代谢产物在大鼠尿液中的排泄情况。

Excretion of methoxyphenamine and its metabolites in rat urine.

作者信息

Niwaguchi T, Inoue T

出版信息

J Chromatogr. 1978 Nov 21;161:223-9. doi: 10.1016/s0021-9673(01)85230-4.

Abstract

Metabolites of methoxyphenamine in urine obtained after oral administration of the drug to rats have been isolated by Sephadex LH-20 column chromatography and identified as the O-, N,O- and N-demethylated derivatives of methoxyphenamine by thin-layer chromatography, spectrometry, and comparisons with synthesized compounds. The unchanged drug and the metabolites excreted in urine have been extracted and determined by gas chromatography after treatment with trifluoroacetic anhydride.

摘要

给大鼠口服甲氧苯丙胺后，通过葡聚糖凝胶LH - 20柱色谱法从大鼠尿液中分离出该药物的代谢产物，并通过薄层色谱法、光谱法以及与合成化合物进行比较，将其鉴定为甲氧苯丙胺的O -、N,O - 和N - 去甲基化衍生物。尿液中排泄的未变化药物和代谢产物经三氟乙酸酐处理后，通过气相色谱法进行提取和测定。